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KMID : 0861020120270030039
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.39 ~ p.55
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The various mechanisms of Korean traditional medicines for anti-cancer
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Park Yeong-Chul
Park Yong-Ki
Lee Sun-Dong
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Abstract
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Objectives: Recently there have been encouraging results, from a western perspective, in the cancer research
field regarding the anticancer effects of herbal medicine. This paper was aimed to review herbal medicine
playing its anticancer role in terms of apoptosis, inflammation control, differentiation and telomerase.
Methods: New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing
anti-cancer effectiveness were reviewed and summarized in terms of pharmacological action.
Results: Ethanol extracts of Spatholobus suberectus greatly inhibited cancer cell growth inducing cell apoptosis
and cytotoxic effects. Scutellaria baicalensis may be responsible for its anticancer activity showing inhibition of
PGE2 synthesis via suppression of COX-2 expression. Saikosaponins isolated from Bupleurum induced the
differentiation of C6 glioma cells, cancer cells, into astrocytes, normal cells. Acetone extract of Bupleurum
scorzonerifolium inhibited proliferation of human lung cancer cells via inducing apoptosis and suppressing
telomerase activity.
Conclusions: Herbal medicine inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects.
Inflammation persisting for a decade eventually elevates the risk of cancer sufficiently that it is discernible in
case control epidemiological studies. Differentiation therapy is defined as a therapy to treat cancers by inducing
differentiation of the stem cells. Telomerase expression is a hallmark of cancer. Nearly the complete spectrum
of human tumors has been shown to be telomerase positive.
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KEYWORD
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Korean traditional medicines, anti-cancer, apoptosis, inflammation, differentiation therapy
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